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MOA|Trial Design|Efficacy|Safety|Dosing and Adminstration

Signifor Is the First Approved Pituitary-Targeted Medical Therapy for Cushing's Disease

Signifor, a novel multireceptor-targeted somatostatin analogue, binds with high affinity to 4 of the 5 somatostatin receptors (ssts), with the highest affinity for sst5, resulting in inhibition of adrenocorticotropic hormone (ACTH) secretion. Signifor represents the first specific treatment for ACTH-secreting pituitary adenomas and is the first approved medical treatment for Cushing's disease.1

In this section you will find information about:

Signifor is indicated for the treatment of adult patients with Cushing's disease for whom surgery is not an option or for whom surgery has failed.1

References: 1. Signifor Summary of Product Characteristics. Novartis Pharma AG. 2. Colao A, Petersenn S, Newell-Price J, et al. A 12-month phase 3 study of pasireotide in Cushing's disease. N Engl J Med. 2012;366(10):914-924. 3. Boscaro M, Barzon L, Fallo F, Sonino N. Cushing's syndrome. Lancet. 2001;357(9258):783-791.

Cushing's Disease

Cushing's disease is a rare hormone
disorder. Statistics indicate
the annual incidence is somewhere
between 1 and 10 new cases per

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